What is a Sequence?
A sequence (also called a cadence or drip campaign) is a pre-planned series of touchpoints—emails, calls, LinkedIn messages, and other communications—sent to prospects over a defined period.
Sequences automate follow-up, ensuring no prospect falls through the cracks while maintaining personalized, multi-channel engagement. Each step in a sequence is triggered by time or prospect behavior.
Example Sequence:
- Day 1: Email #1 (value-focused)
- Day 3: Email #2 (case study)
- Day 5: Call attempt
- Day 7: LinkedIn connection request
- Day 10: Email #3 (breakup/alternative angle)
Why Sequences Matter
Consistency:
75% of qualified leads aren't ready to buy immediately. Sequences maintain consistent contact without relying on individual rep discipline.
Efficiency:
Instead of remembering to follow up with 100+ prospects, reps set up sequences once and let automation handle execution.
Multi-Touch Strategy:
It takes 8-12 touchpoints to reach decision-makers. Sequences make this scalable without overwhelming manual effort.
Response Rates:
Sequences with 5-7 steps see 2x higher response rates compared to single-email outreach.
Types of Sequences
1. Outbound Sequences
Cold Prospecting:
- Target: New prospects matching ICP
- Goal: Book initial meeting
- Length: 7-14 touches over 3-4 weeks
- Channels: Email, phone, LinkedIn, social
- Target: Prospects showing buying signals (hiring, funding, news)
- Goal: Connect while opportunity is timely
- Length: 5-8 touches over 2 weeks
- Personalization: High (reference specific trigger event)
2. Inbound Sequences
Lead Nurture:
- Target: Leads who downloaded content or requested info
- Goal: Educate and advance to sales conversation
- Length: 5-7 touches over 2 weeks
- Focus: Educational content, case studies
- Target: Prospects who booked but missed meetings
- Goal: Reschedule and maintain momentum
- Length: 3-5 touches over 1 week
- Tone: Helpful, understanding
3. Opportunity Sequences
Post-Demo Follow-Up:
- Target: Prospects after initial presentation
- Goal: Advance to next stage or proposal
- Length: 5-8 touches over 3 weeks
- Content: ROI analysis, case studies, trial offers
- Target: Opportunities gone cold
- Goal: Re-engage and revive conversation
- Length: 3-5 touches
- Approach: New value angle, check-in, alternatives
4. Customer Sequences
Onboarding:
- Target: New customers
- Goal: Successful implementation and activation
- Length: Ongoing during onboarding period
- Target: Existing customers with expansion potential
- Goal: Identify and close additional revenue
Building Effective Sequences
1. Define Your Objective
Clarify the Goal:
- Book a meeting
- Get a demo signup
- Revive stalled opportunity
- Cross-sell additional product
2. Choose Your Channels
Channel Mix Options:
- Email-only: Simplest, lowest cost
- Email + phone: Higher response, more resource intensive
- Multi-channel: Email, phone, LinkedIn, direct mail, video
Use at least 2 channels for better response rates. Video and direct mail show strong ROI for high-value targets.
3. Plan Your Timing
Effective Cadences:
- Aggressive: Daily touches for 3-5 days
- Standard: Touches every 2-3 days for 3-4 weeks
- Long nurture: Weekly touches for 6-8 weeks
- Space emails 2-3 days apart
- Call within 1 hour of email open
- Alternate channels to avoid fatigue
- End with clear "breakup" message
4. Craft Compelling Content
Email Subject Lines:
- Keep under 50 characters
- Reference specific value or pain point
- Avoid salesy language ("amazing opportunity")
- Test variations for performance
- Lead with value, not features
- Include social proof
- Keep emails under 150 words
- One clear call-to-action per email
- Personalize beyond just name
5. Set Trigger Rules
Conditional Branching:
- If email opened → send follow-up in 2 days
- If no response → add phone call
- If replied → remove from sequence, rep takes over
- If link clicked → send relevant case study
2024 Sequence Best Practices
Personalization at Scale
Tiered Approach:
- Tier 1 (Enterprise): Highly personalized, video intros, research-heavy
- Tier 2 (Mid-market): Moderate personalization, some research
- Tier 3 (SMB): Template-based with basic personalization
AI-Enhanced Sequences
2024 Capabilities:
- AI-generated personalized first lines
- Automated research integration
- Optimal send time prediction
- Content optimization based on engagement
Compliance Considerations
GDPR/CAN-SPAM:
- Clear unsubscribe option in every email
- Physical mailing address included
- Accurate sender identification
- Honor opt-outs immediately
Measuring Sequence Performance
Key Metrics
| Metric | Description | Good Benchmark |
|---|---|---|
| Open Rate | Emails opened / sent | 25-40% |
| Reply Rate | Replies / emails sent | 5-15% |
| Meeting Rate | Meetings booked / touched | 1-3% |
| Unsubscribe Rate | Opt-outs / sent | <1% |
| Spam Complaints | Spam reports / sent | <0.1% |
Optimization Process
- Launch sequence with initial design
- Track metrics for 100+ prospects
- Identify weak steps (low open, high drop-off)
- Test variations (subject lines, timing, content)
- Iterate and improve continuously
Common Sequence Mistakes
- Too many emails – More than 8-10 touches creates fatigue
- Spacing too close – Daily emails feel spammy
- Generic content – Template-only outreach underperforms
- No breakup step – Leaving prospects in permanent sequence is annoying
- Ignoring replies – Failing to remove responders from automation
- Single-channel reliance – Email-only sees lower response rates
- Not testing – Launching without A/B testing variations
Key Takeaways
- Sequences automate multi-touch follow-up across email, phone, and social channels
- Key types: outbound prospecting, inbound nurture, opportunity follow-up, customer sequences
- Effective sequences: 5-8 touches over 2-4 weeks with 2+ channels
- Personalize based on tier (enterprise, mid-market, SMB)
- Track open rate, reply rate, meeting booking, unsubscribe rate
- Use conditional branching based on prospect behavior
- Always include breakup step and honor opt-outs
- Test and optimize continuously for better performance
Related Terms
SAL (Sales Accepted Lead)
Lead accepted by sales for qualification. Bridge between MQL and SQL.
Sales Cadence
Structured sequence of touchpoints over time.
Sales Champion
Internal advocate promoting your solution. Key to enterprise deals.
Sales Cycle
Time from first contact to closed deal. Varies by deal size.